Hereafter freshly isolated CD44v6 (+)/EpCAM (+)/ALDH1 (+)/CD133 (+) cells from the corresponding sphere-propagated tumor cells will be referred to as CICs, and CD44v6 (–)/EpCAM (+)/ALDH1 (+)/CD133 (+) cells as Non-CICs (Figure 3D). This evidence concerns the gene ALDH1A1 and neoplasm.