PROM1 and neoplasm: Together, these data collectively support a model in which drug resistant colorectal CICs are confined to the small CD44v6 (+)/EpCAM (+)/ALDH1 (+)/CD133 (+) cell populations isolated from sphere-propagated tumor cells (as seen in Figure 3D), which are enriched with FOLFOX therapy (Figure 4I) with high tumorigenic potential (Figures 4B-H).