NLRP3 and metabolic dysfunction-associated steatohepatitis: The NLRP3 inflammasome which comprises NOD-like receptor family pyrin domain-containing 3 (NLRP3), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and caspase-1 cooperates with ER stress and mitochondria damage in the pathogenesis of many liver disorders such as ASH, NAFLD, nonalcoholic steatohepatitis (NASH), hepatic ischemic injury, and hepatotoxicity (18, 19).