FASLG and intracerebral hemorrhage: However, increasing CHMP4B levels were accompanied by the upregulation of Fas receptor (Fas), Fas ligand (FasL), active caspase-8, and caspase-3 in neurons, which implicated a proapoptotic function in neuronal cells induced by hemin stimulation following intracerebral hemorrhage (ICH) via the extrinsic apoptotic pathway (50) (Figure 1 and Table 1).