CHMP2A depletion or mutation induces iDISC-mediated non-canonical caspase-8 activation on immature autophagosomal membranes and leads to ATG5- and LC3-II-positive phagophore accumulation, and redirects protumorigenic autophagy to apoptosis in osteosarcoma and neuroblastoma cells, thus inhibiting mouse xenograft model tumor growth (109–111), which may open new avenues for therapeutic targeting of autophagy in cancer. This evidence concerns the gene CHMP2A and osteosarcoma.