Starvation-induced ESCRT-III components (CHMP2A, CHMP2B, CHMP3, CHMP7, and CEP55) as well as VPS4 acted as potential regulators of phagophore closure, dissociated from the autophagic membrane, participated in nuclear envelope reformation, and directly mediated membrane scission in human bone osteosarcoma epithelial cells (U-2 OS), HeLa cells, and human retinal pigment ephitilial-1 cells under basal and starved conditions (61, 67–69). This evidence concerns the gene CHMP2A and osteosarcoma.