STING1 and neoplasm: Our data are in line with previous findings indicating STING-induced tumor vascular remodeling, which promotes vascular normalization and correlates with enhanced T-cell infiltration and prolonged survival in human colon and breast cancer (47, 48). We also assessed the level of acidity within treated tumors using ICG-pHLIP as an acidity probe: the tumor acidity was significantly reduced (by 72%) within three days after treatment compared to the control group.