A bubble chart created using seven different algorithms later revealed that the risk score was negatively correlated with B cells, T cell CD8+, T cell CD4+, and cancer-associated fibroblast, while positively correlated with T cell CD4+ Th1, T cell CD4+ Th2, NK cell resting, and mast cell resting (Figure 8(b), Table S3). This evidence concerns the gene CD4 and cancer.