Consistent with the RNA-seq data, the mRNA levels of COL5A2 and HOXB4 were lower and UNC5B mRNA levels were higher in RSL3-treated cells than in control cells (Figures 12A–F), indicating the probable roles of the three FAGs in the ferroptotic processes of osteosarcoma cells. Here, COL5A2 is linked to osteosarcoma.