DHDDS and ovarian cancer: For example, in ovarian cancer, increased HOXB4 expression was associated with a worse prognosis, and HOXB4 overexpression enhanced the malignant evolution of ovarian cancer through the transcriptional regulation of the dehydrodolichyl diphosphate synthase subunit (DHDDS) (Li et al., 2020b), whereas increased HOXB4 expression in cervical cancer obviously inhibited cell proliferation and reduced tumorigenic potential (Lei et al., 2021).