Common mutations in the high-risk group also included BAP1, KDM5C, FLG, and PTEN, whereas common mutations in the low-risk group included ANK3, KMT2C, ATM, and CSDM3. In addition, patients in the group with high risk had a higher tumor mutational burden (TMB) (Figure 9C). This evidence concerns the gene KDM5C and neoplasm.