\Lewandowski et al. (2020) observed that nearly 90% of obese participants were CT genotype of rs4880 in SOD2. Flekac et al. (2008) investigated the serum SOD activity and frequency of allele and genotype of SOD2 between T2DM and healthy controls, and found that the SOD activity was higher in CC genotype of SOD2 gene than TT. This evidence concerns the gene SOD1 and type 2 diabetes mellitus.