In addition, variants in membrane bound O-acyltransferase domain containing 7 (MBOAT7), fat mass and obesity-associated (FTO), and superoxide dismutase 2 (SOD2) which have been reported to be involved in the regulation of inflammatory lipid pathways, lipogenesis, and oxidative stress, respectively, contributed to variation in NAFLD, with the most severe being non-alcoholic steatohepatitis (NASH) and fibrosis (Al-Serri et al., 2012; Guo et al., 2013; Meroni et al., 2020; Teo et al., 2021). Here, SOD2 is linked to obesity due to melanocortin 4 receptor deficiency.