Although there were no significant differences in the frequency of A allele and G allele of rs4880 in SOD2 gene between lean NAFLD and lean non-NAFLD individuals, the AA genotypic frequency of rs4880 in SOD2 gene was much lower in lean NAFLD patients than lean non-NAFLD individuals (p = 0.005, FDR adjusted p = 0.059). Here, SOD2 is linked to metabolic dysfunction-associated steatotic liver disease.