WFS1 pathogenic variants have been linked to Wolfram and Wolfram-like syndromes, which include cases with just one pathogenic variant in heterozygosis not meeting the WS diagnostic criteria (Barrett et al., 1995; Inoue et al., 1998; Takei et al., 2006; Heredia et al., 2013; Blanco-Aguirre et al., 2015). The gene discussed is WFS1; the disease is Wolfram-like syndrome.