The patient showed the full characteristic spectrum of WS symptoms, probably because two compound heterozygotic pathogenic variants were found in WFS1. Current data available suggest that the spectrum of symptoms shown by WS and Wolfram-like patients might be due to wolframin levels in the pancreatic beta-cells and visual and auditory pathways, but still, the difference in wolframin levels does not explain the variability in the onset and order of appearance of the symptoms. The gene discussed is WFS1; the disease is Werner syndrome.