CircRNA_002581 can sponge miR-122 to increase cytoplasmic polyadenylation element-binding protein 1 (CPEB1) expression, which can downregulate PTEN, and then inhibit the AMPK-mTOR pathway to downregulate autophagy in the NASH-like cell model (118). This evidence concerns the gene CPEB1 and metabolic dysfunction-associated steatohepatitis.