Inflammatory myelopathies can be recognized in the context of numerous immune-mediated disorders, including multiple sclerosis (MS), aquaporin-4(AQP4)-IgG-positive neuromyelitis optica spectrum disorders (AQP4+NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). This evidence concerns the gene AQP4 and myeloid sarcoma.