Using an OP9-DL1 co-culture system we established an immortalized Idh2R140Q/NHD13 DN cell line and found that treatment of these immortalized cells with AG-221 led to marked decrease in cell proliferation suggesting targeting IDH2 mutations may be an effective treatment for EITP-ALL as well as AML. Here, IDH2 is linked to acute myeloid leukemia.