IDH1 and acute myeloid leukemia: Coincidentally, whole exome sequencing of AML which developed in mice that expressed a NUP98-HOXD13 (NHD13) transgene revealed that 21% of these samples had acquired an Idh1p.R132H mutation, suggesting that an NHD13 transgene might collaborate with an Idh1/2 mutation to generate AML [11].