Using whole exome sequencing we were able to show that acquired mutations in human EITP-ALL (such as KRAS, NRAS, PTPN11, JAK3, SH2B3, SETD2, and EZH2) were enriched in Idh2R140Q/NHD13 DN1/DN2 T-ALL, and NOTCH1 mutations, which are less common in EITP T-ALL were also less common in the Idh2R140Q/NHD13 DN1/DN2 T-ALL. Here, SH2B3 is linked to acute lymphoblastic leukemia.