As tumour growth and associated angiogenesis were significantly reduced in conditional mice with ARF6 gene deletion in endothelial cells or pharmacological inhibition of general receptor for 3-phosphoinositides 1, this study therefore suggested that the effect of ARF6 on angiogenesis and tumour progression occurs via HGF-dependent β1 integrin recycling. The gene discussed is ARF6; the disease is neoplasm.