Indeed, FAK activation associated with α5 upregulation in response to c-Met inhibitor cabozantinib appears to reduce its anti-tumour effects, whereas combination of cabozantinib with FAK inhibitor CT-707 improves therapeutic activity as shown through increased apoptosis in vitro and reduced tumour growth in HCC xenografts (Wang et al., 2016). This evidence concerns the gene MET and hepatocellular carcinoma.