Hepatocellular carcinoma (HCC)-specific computational model of HGF/c-Met axis supports the findings of experimental studies reporting enhanced inhibition of phosphorylated AKT and ERK1/2 upon c-Met-α5β1 dissociation and highlights the importance of previously identified c-Met-β1 co-trafficking (Jafarnejad et al., 2019; Barrow-Mcgee et al., 2016). Here, AKT1 is linked to hepatocellular carcinoma.