It has been documented that impaired ZIP8, usually caused by mutations in the SLC39A8 gene, is responsible for diseases such as type II congenital disorder of glycosylation (Riley et al., 2017; Choi et al., 2018), cardiovascular diseases (Zhang et al., 2016), severe idiopathic scoliosis (Haller et al., 2018), schizophrenia (McCoy et al., 2019), Crohn’s disease (chronic inflammation of the digestive system) (Li et al., 2016), and Leigh syndrome (a severe inherited neurodegenerative disease) (Choi et al., 2018). Here, SLC39A8 is linked to Crohn disease.