However, the use of mdivi-1 treatment in clinically relevant large animal models of myocardial infarction did not reduce the size of myocardial infarction or improve cardiac function, so the relevant studies still need to be validated in large samples (Ong et al., 2019); CDGSH iron-sulfur domain protein 2 (Cisd2) is critical for mitochondrial integrity and intracellular Ca2+homeostasis. Here, CISD2 is linked to myocardial infarction.