Huang C. Y. Team from China Med Univ’s has been working on the treatment of HF through mitophagy for a long time, and has found that IGF-IIR can induce mitophagy through Rab9-dependent selective autophagy, which provides a new idea for the treatment of HF (Huang et al., 2018a; Huang et al., 2018b). Here, RAB9A is linked to hydrops fetalis.