PPARA and hydrops fetalis: It has also been found that trimetazidine can improve isoproterenol-induced myocardial metabolic remodeling in HF rats by activating AMPK and PPARα to regulate myocardial substrate utilization, especially ketone body metabolism (Li et al., 2020); It has been found that mitochondrial quality control regulators are also potential new drug targets in mitochondrial therapy.