GPX4 and pancreatic neoplasm: In recent decades, multiple study showed that mTOR pathway was discovered to regulate ferroptosis, for example, Zhang et al. discovered that benzopyran derivative 2-imino-6-methoxy-2H-chromene-3-carbothioamide (IMCA) can induce ferroptosis SLC7A11-depend through AMPK/mTOR pathway [29]; Liu et al. found that RSL3, a ferroptosis inducer, can suppress mTOR activity to induce the protein degradation of GPX4 in human pancreatic cancer cells [30].