Reduce blood glucose and glycated hemoglobin, serum ALT, TNF-α, IL-6 levels, glucose intolerance, and hepatic lipid accumulation, down-regulate hepatic gene expression of triglyceride and cholesterol synthesis as well as inflammation (TLR4, MyD88, NF-κb1, TNF-α, and IL-6). Here, MYD88 is linked to Glucose intolerance.