Pregnancy or lactation; ALT or AST level of >5-times the upper limit of normal; platelet count of <50×103/μl; rheumatic and immune diseases, cancer, and other related diseases; on immunosuppressant; hypersensitivity to tocilizumab; active hepatitis and tuberculosis; specific bacterial and fungal infection; history of organ transplantation; and mental disorders. The gene discussed is GPT; the disease is immune system disorder.