PGF and neoplasm: The average total treatment time was 86 h, after 3 months of treatment, the average mass thickness of 34 cases (94%) were halved, and the tumor disappeared at followed up of 11 months Chen et al. studied patients with choroidal melanoma and showed that the concentrations of VEGF-A and placental growth factor (PLGF) in the aqueous humor of patients with uveal melanoma (UM) increased after Iodine125 plaque therapy (16).