Based on the huge population base of long-term hospitalized schizophrenic patients in China, the present research analyzed the factors affecting the PRL levels of long-term hospitalized patients, especially the patients with T2DM, in comparison with common metabolic indexes and PRL levels of co-T2DM and non-comorbid T2DM of schizophrenic patients. The gene discussed is PRL; the disease is type 2 diabetes mellitus.