Immunoglobulins are divided into five classes, namely, IgG, IgA, IgM, IgD and IgE, and a remarkable alleviation in immunodeficiency diseases, such as HIV, chronic lymphocytic leukemia, and thrombocytopenia, has been seen after injection of synthetic immunoglobulin (55). The gene discussed is IGHE; the disease is immunodeficiency disease.