An emerging tumor microenvironment is a complex and continuously evolving entity composed of tumor cells and tumor stromal cells such as stromal fibroblasts, endothelial cells, and immune cells like microglia, macrophages, lymphocytes, and the non-cellular components such as collagen, fibronectin, hyaluronan, and laminin which make up the extracellular matrix (ECM) of tumor microenvironment [81]. This evidence concerns the gene LAMB2 and neoplasm.