found commonly genomic alterations in LCNEC including the genes for p53 (TP53; 78%), retinoblastoma (RB1; 38%), serine/threonine kinase 11 (STK11; 33%), kelch-like ECH associated protein 1 (Keap1; 31%) and the Kirsten rat sarcoma viral oncogene (KRAS) (22%). The gene discussed is KEAP1; the disease is large cell neuroendocrine carcinoma.