PRKCA and triple-negative breast carcinoma: Apart from its above-mentioned functions, PKC-α expression maintains the invasiveness of triple-negative breast cancer (TNBC) and endocrine resistant cell lines through upregulation of FOXC2, a transcriptional repressor of p120-catenin (CTNND1); a high FOXC2:CTNND1ratio was also associated with shorter disease free survival in TNBC patients in The Cancer Genome Atlas (TCGA) dataset (48).