TFs, including STAT3 (43), SP1 (44), USF1 (45), USF2 (46), YY1 (47), EGR1 (48), FOXA1 (49), E2F1 (50), NRF1 (51), SRF (52), PPARG (53), JUND (54), TP53 (55), and HNF4A (56), were identified as being associated with the development of DN. The gene discussed is NRF1; the disease is liver dysplastic nodule.