TFs, including STAT3 (43), SP1 (44), USF1 (45), USF2 (46), YY1 (47), EGR1 (48), FOXA1 (49), E2F1 (50), NRF1 (51), SRF (52), PPARG (53), JUND (54), TP53 (55), and HNF4A (56), were identified as being associated with the development of DN. This evidence concerns the gene E2F1 and liver dysplastic nodule.