Many factors have been reported to be involved in the development and progression of cancer in DM, including hyperinsulinemia (8), elevated free insulin-like growth factor-1 (IGF-1) level (9), impaired IGF binding protein (IGFBP)/IGF/IGF receptor (IGFR) axis, and inflammatory cytokines (10). This evidence concerns the gene IGF1 and Hyperinsulinemia.