ARID1A depletion accelerates epithelial-mesenchymal transition, increases cancer stemness and promotes migration, invasion and angiogenesis in various cancers, including breast cancer, uterus cancer and pancreatic cancer by reducing the chromatin accessibility of target genes or influencing the post-transcriptional modification process (Wilson et al., 2019; Luo et al., 2020; Wang et al., 2020; Tomihara et al., 2021). Here, ARID1A is linked to pancreatic neoplasm.