The knockout of BNIP3 in mice can inhibit mitosis through the interaction of BNIP3 and LC3, with the manifestations of increased autophagy, decreased apoptosis and reduced cerebral infarction, indicating that the silencing of BNIP3 may be conducive to the neuroprotection after stroke (Shi et al., 2014). Here, BNIP3 is linked to Stroke.