In tMCAO mice, the knockdown of circHectd1 can significantly decrease cerebral infarct size, neuronal deficits, and astrocyte activation, though miR-142 targets TCDD inducible poly[ADP-ribose] polymerase (TIPARP) and inhibits the astrocyte activation via macroautophagy/autophagy (Han et al., 2018). Here, TIPARP is linked to cerebral infarction.