The downregulation of circ_0001588 upregulates miR-211-5p and induces the Sirt1/nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway to prevent oxidative stress in AD (Zhu et al., 2020). This evidence concerns the gene NFE2L2 and Alzheimer disease.