Circ_0000950 sponging miR-103 increases the expression of prostaglandin-endoperoxide synthase 2 (PTGS2) and elevates the levels of inflammatory cytokines [interleukin-1β (IL-1β), IL-6, and tumor necrosis factor α (TNF-α)] to inhibit neurite outgrowth and promote neuron apoptosis in AD (Yang et al., 2019). This evidence concerns the gene TNF and Alzheimer disease.