Different known oncogenic pathways lead to the dysregulation of polyamine metabolism, including MYC signaling, RAS/RAF/MEK/ERK signaling pathway, AKT signaling66PTEN/PI3K/mTORC1,67 and the activation of the non‐canonical WNT signaling pathway which appears to be associated with decreased citrate and spermine levels in the most aggressive phenotypes of PCa.68 This evidence concerns the gene MYC and posterior cortical atrophy.