AKT1 and posterior cortical atrophy: Different known oncogenic pathways lead to the dysregulation of polyamine metabolism, including MYC signaling, RAS/RAF/MEK/ERK signaling pathway, AKT signaling66PTEN/PI3K/mTORC1,67 and the activation of the non‐canonical WNT signaling pathway which appears to be associated with decreased citrate and spermine levels in the most aggressive phenotypes of PCa.68