The Epac2–/– mice GM was characterized by significant alterations in several taxa which have been previously associated with metabolic diseases, including Mucispirillum [62], Oscillibacter [63], Marvinbryantia [64], Helicobacter [65], RC9 gut group [66], Thalassospira [67] and Epsilonbacteria [68]. The gene discussed is RAPGEF4; the disease is metabolic disease.