The inconsistency in BW and glucose intolerance in various studies may be owning to differences in the fat content of the diets, the age of HFD initiation, duration of HFD feeding, glucose tolerance test techniques (OGTT versus IPGTT), and generation of KO mice with different approaches in deletion of Epac gene [26, 55, 75–77]. The gene discussed is RAPGEF4; the disease is Glucose intolerance.