Lower lyso-Gb1 concentration was observed in patients who had achieved all 6 therapeutic goals, assessed by the extent of hepatomegaly, splenomegaly, anemia (hemoglobin level), thrombocytopenia (platelet count), bone pain, and bone crisis, than in those who had not achieved all 6 therapeutic goals. This evidence concerns the gene GABBR1 and Splenomegaly.