By analyzing HSD11B2 expression in vitro and in vivo in rats, Alikhani-Koopaei et al. found that high methylation of CpG islands in the HSD11B2 promoter reduced gene expression, which was potentially associated with hypertension, and that the inhibition could be reversed by inducing demethylation [65]. The gene discussed is HSD11B2; the disease is hypertensive disorder.