To date, mutations in six genes, namely microphthalmia-associated transcription factor (MITF), paired box 3 (PAX3), endothelin 3 (EDN3), endothelin receptor type B (EDNRB), SRY Box 10 (SOX10), and snail homolog 2 (SNAI2), are responsible for WS. This evidence concerns the gene SNAI2 and Werner syndrome.