FOXC2 and lymphedema: The deleted fragment in our fetus includes the other three genes—FOXC2, FOXL1 and FENDRR. FOXC2 is the key gene of LDS characterized by lymphedema of the limbs and double rows of eyelashes [14, 24], which is essential for lymphatic valve maintenance by regulating lymphatic endothelial cells junctional integrity and cellular quiescence [25].