FOXF1 and hypoplastic left heart syndrome: Hence, the haploinsufficiency of FOXF1 gene is related with manifestations of lung, gastrointestinal and urinary tracts such as HLHS, duodenal atresia and distal ureteral dilatation [5, 16, 22] because of point disease-causing variant of FOXF1 or CNV deletions overlapping FOXF1 or the change of its upstream regulatory region located ~ 270 kb upstream to FOXF1 gene (chr16:86178434-86238313, hg19) [4].