To examine the role of TRIM46 in the context of viral infection, we examined the expression levels of IFNA and IFNB1. Knockdown of TRIM46 increased IFNA and IFNB1 mRNA expression levels during influenza H7N9 infection (Fig. 4A, B), meanwhile, ectopic expression of TRIM46 decreased IFNA and IFNB1 mRNA levels (Fig. 4D, E). The gene discussed is IFNB1; the disease is viral infectious disease.