AGTR1 and Stroke: In addition, we suggest deep phenotyping related to SD in further genetic models of salt-sensitivity such as Dahl salt-sensitive rats to determine whether the dysfunctional aldosterone-ENaC-endogenous ouabain-AT1R cascade in the brain,50 is generally or only partially associated with an increased propensity for SD and inverse hemodynamic responses, as this may offer novel targets for the treatment of a number of important clinical conditions and stroke in particular.28,31,81