Nevertheless, the tumor microenvironment and immune status is highly heterogeneous across tumor entities: For example, immunosuppression more strongly prevails in IDH-wild-type glioblastoma, whereas IDH-mutant astrocytomas secrete granulocyte colony-stimulating factor which increases the ratio of non-suppressive neutrophils [11]. Here, CSF3 is linked to astrocytoma (excluding glioblastoma).