Although these results suggest a potential dependency on DNMT1 mutation that correlated with DNMT3A mutational status, the subtlety of these results as well as the inconsistency across multiple isogenic cell lines pairs tested preclude us from basing any conclusions on a dependency for DNMT1 in DNMT3A-mutated AML. The gene discussed is DNMT3A; the disease is acute myeloid leukemia.