Of the AML cell lines screened, OCI-AML2 and OCI-AML3, which are both mutant for DNMT3A, exhibited some of the strongest gene effects in both the CRISPR and RNAi datasets compared to the other AML lines screened, which are wild-type for DNMT3A (Fig. 1a). Here, RUNX2 is linked to acute myeloid leukemia.