ProTiler was next run on the AML cell lines mutant for DNMT3A. Several CKHS regions within DNMT1 were identified in the OCI-AML2 and OCI-AML3 datasets, again covering the BAH1, and MTase domains in both cell lines, and additionally the RFTS and BAH2 domains in OCI-AML2 cells. This evidence concerns the gene RUNX2 and acute myeloid leukemia.