For example, glucocorticoid-remediable aldosteronism (GRA) is an autosomal disorder that occur when the promoter region of 11 β-hydroxylase gene (CYP11B1) and the coding regions of the aldosterone synthase (CYP11B2) gene unequally crosses over on chromosome 8q. This evidence concerns the gene CYP11B1 and glucocorticoid-remediable aldosteronism.