CYP11B2 and glucocorticoid-remediable aldosteronism: For example, glucocorticoid-remediable aldosteronism (GRA) is an autosomal disorder that occur when the promoter region of 11 β-hydroxylase gene (CYP11B1) and the coding regions of the aldosterone synthase (CYP11B2) gene unequally crosses over on chromosome 8q.