There were no differences in the proportion of male sex, current smoker, regular drinker, and low income; BMI and blood pressure; TC, FPG, HOMA-IR, hs-CRP, hemoglobin, and creatinine; in the prevalence of diabetes, hypertension, dyslipidemia, and obesity between the frail and non-frail groups. The gene discussed is CRP; the disease is hypertensive disorder.