CLU and cancer: Although others have suggested a role of non-glycosylated CLU proteins generated from CLU mRNA lacking exon 2, this has only been demonstrated in immortal cancer cell lines using overexpression studies41–43, we are the first to generate iPSCs and iPSC-neurons lacking exon 2 and increased non-glycosylated CLU proteins in the absence of non-glycosylated CLU proteins.