The same pattern was observed when considering the subgroup of patients without familial history of cancer (FH(−)) (Fig. 3); in this case BOADICEA and PennII models were the best predictors of PV/LPV carriers in BRCA1 (AUC = 0.807, p < 0.001; and AUC = 0.764, p = 0.025, respectively), but were poor predictors of PV/LPV carriers in BRCA2 (AUC < 0.500, p > 0.05 in both cases). This evidence concerns the gene BRCA2 and cancer.