In the subgroup of patients with familial history of cancer (FH(+)) (Fig. 3), when the number of relatives with cancer was used as a predictor of PV/LPV carriers it outperformed both prediction models for BRCA2 (AUC = 0.739, p < 0.001), for BRCA1/2 (AUC = 0.670, p < 0.001), and for BRCA1/2 and TP53 (AUC = 0.651, p = 0.004). Here, BRCA1 is linked to cancer.