BRCA1 and cancer: Regarding the variants classified as VUS, 10.5% of the 257 patients presented VUS in BRCA1/2, with no VUS detected in TP53. Two VUS called our attention due to the familial history of cancer of the proband: carrier of BRCA1 c.1881C > G (p.Val627 =) reported six relatives diagnosed with HBOC core tumors; while the carrier of BRCA2 c.5096A > G (p.Asp1699Gly) reported eight relatives diagnosed with cancer, but only two with HBOC core tumors.