Of the 16 patients that presented first tumors other than HBOC core tumors in the study cohort, none presented PV/LPV, and only one presented a VUS in BRCA1 (c.5348T > C, p.Met1783Thr; see Fig. 2), with thyroid cancer as first malignancy and BC as the second. The gene discussed is BRCA1; the disease is breast cancer.