Up to the age of 80, women harboring PV/LPV in BRCA1 and BRCA2 genes have a cumulative risk of 72% and 69% for developing BC, and of 44% and 17% for developing OC, respectively, compared to 12% lifetime risk of developing BC and 1% of developing OC for women in the general population7. Here, BRCA1 is linked to breast cancer.