In turn, when the familial history of cancer was used as a predictor of PV/LPV carriers, it outperformed BOADICEA and PennII for BRCA2, for BRCA1/2, and for BRCA1/2 plus TP53; similar results were observed when the number of relatives with HBOC core cancer was used as a predictor. This evidence concerns the gene BRCA1 and cancer.