We further compared three melanoma cell lines bearing Fbxo4 mutations Lu1205I377M-Fbxo4, WM739BI377M-Fbxo4, WM3918I377M-Fbxo4, two cell lines harboring FBXO4wt (WM983Bwt-Fbxo4, WM35wt-Fbxo4) versus primary human melanocytes (PHM80 and PHM90). The gene discussed is FBXO4; the disease is melanoma.