RIPK3 and Splenomegaly: Since RIPK3 and Caspase8 double deficient mice suffer from lymphadenopathy and splenomegaly at an old age41,42, we compared Ripk1+/+, Ripk1Y383F/Y383F, Ripk3−/−Caspase8−/− and Ripk1Y383F/Y383FRipk3−/−Caspase8−/− mice side by side at a young age at 8 weeks and old age at 16 weeks.