LncRNA DUXAP8 is located on chromosome 20q11, and the upregulation of DUXAP8 has been reported in multiple cancers, including gastric cancer,12 lung cancer,13 bladder cancer,14 renal cell carcinoma,15 hepatocellular carcinoma,16 neuroblastoma17 and colorectal cancer.18 DUXAP8 acts as an oncogene in several cancer types through an EZH2-dependent mechanism13 or by regulating PTEN expression.14 However, the expression pattern and impact of DUXAP8 on development of BC radioresistance remain unknown. This evidence concerns the gene EZH2 and breast cancer.