It has been reported that lncRNAs can interplay with miRNAs and antagonize the repressive activity of miRNAs on gene expression in tumor cells.5 For instance, DUXAP8 was shown to function as a sponge for miR-577 to promote the migration and invasion of colorectal cancer cells.18 Moreover, DUXAP8 enhances the progression of renal cell carcinoma via downregulating miR-126.15 Interestingly, miR-126 has been shown to increase chemosensitivity in drug-resistant gastric cancer cells by targeting EZH2.31 We found that forced expression of DUXAP8 induced the levels of EZH2 in BC cells. This evidence concerns the gene EZH2 and breast cancer.