DUXAP8 and hereditary clear cell renal cell carcinoma: It has been reported that lncRNAs can interplay with miRNAs and antagonize the repressive activity of miRNAs on gene expression in tumor cells.5 For instance, DUXAP8 was shown to function as a sponge for miR-577 to promote the migration and invasion of colorectal cancer cells.18 Moreover, DUXAP8 enhances the progression of renal cell carcinoma via downregulating miR-126.15 Interestingly, miR-126 has been shown to increase chemosensitivity in drug-resistant gastric cancer cells by targeting EZH2.31 We found that forced expression of DUXAP8 induced the levels of EZH2 in BC cells.