Abnormal EZH2 expression and the constitutive activation of PI3K/AKT/mTOR signaling contribute to the malignant progression of BC.31–33 In this study, we found that DUXAP8 could enhance the radioresistance in BC cells via recruiting EZH2 to the target genes and by activating the PI3K/AKT/mTOR pathway. This evidence concerns the gene DUXAP8 and breast cancer.