Given the GATA-3 dependency observed, its expression across the continuum of T-cell neoplasms derived from immature (thymic) and mature (post-thymic) T cells, and its association with a clinically aggressive variant in CTCL, we performed doxycycline-inducible shRNA-mediated knockdown studies in a panel of well characterized CTCL (n = 3) and T-ALL (n = 4) cell lines using previously characterized shRNA [(1), and Fig. S1B]. Here, GATA3 is linked to T-cell and NK-cell neoplasm.