CMV infection induces inflammatory responses that may modulate the immune system, such as the upregulation of TNF-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α, IP-10 and complement C2 in the plasma and HLA-DR expression on CD4+ T-cells and CD8+ T-cells. The gene discussed is CD8A; the disease is cytomegalovirus infection.