Interestingly, the scaffolding subunit that acts to immobilize and stabilize the catalytic subunit to promote LCMT-1 interaction and drive enhanced carboxymethylation of the catalytic subunit is the most frequently mutated subunit of PP2A in cancer, suggesting that cancer selects multiple mechanisms to disrupt PP2A carboxymethylation (61). This evidence concerns the gene LCMT1 and cancer.