PR130 directs PP2A activity toward tumor promoting and suppressive means in a context-dependent manner across cancer, as elevated expression of PR130 may drive cancer progression by accelerating proliferation and enhancing migratory behavior in HCC while depletion of PR130 in fibrosarcoma, breast cancer, and colorectal cancer cells augmented cellular adhesion to collagen I, resulting in impaired cell migration (125, 126, 127, 128, 129, 130). This evidence concerns the gene PPP2R3A and breast cancer.