Nowadays, the interaction between Th17 and NLRP3 inflammasome, as well as the regulation of NLRP3 inflammasome on Th17 cells differentiation, was studied mainly in autoimmune diseases, infectious diseases, and inflammatory diseases, such as lupus23, pulmonary paracoccidioidomycosis24, and rheumatoid arthritis25. The gene discussed is NLRP3; the disease is autoimmune disease.